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The permeability of the capillaries was determined by comparing the hematocrit and the concentration of proteins and fluids in both arterial and venous blood, calculated as described elsewhere [7]. Sampling of arterial blood from the carotid arteries ; and venous blood from the cerebral venous stock sinus ; was done simultaneously, and the amount of water ml ; and proteins % ; passing through the capillary wall was determined [8]. The permeability of the capillaries was also determined by comparing the hematocrit and the amount of proteins in both arterial and venous blood. The direction of movement in cerebral capillaries was defined as a plus sign + ; for movement of fluid and protein from the tissues to the blood and a minus sign - ; from the blood into the tissues [7]. Statistical analysis In all cases, values are given as means SEM of 8 animals. Statistics were performed by unpaired Student's ttest * means p 0.01. 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